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Safety Information

Treatment: NAD+
Last Updated: September 1, 2025

Important Safety Information Regarding Compounded NAD+

Compounded Medication Disclaimer

Compounded medications, including NAD+ (nicotinamide adenine dinucleotide), are not approved by the U.S. Food and Drug Administration (FDA) and do not undergo the same clinical studies as FDA-approved drugs to evaluate safety or efficacy. Compounded medications may still be legally prescribed when determined appropriate by a licensed healthcare provider following a medical consultation.

Eligibility

NAD+ therapy may be considered for adults experiencing symptoms such as fatigue, low energy, cognitive decline, or those seeking longevity-focused support. Eligibility is determined on a case-by-case basis. A licensed healthcare provider will review your intake to confirm eligibility and ensure treatment is safe and appropriate for you.

Indication

NAD+ is a vital coenzyme found in every cell of the body. It is essential for energy production, mitochondrial function, and DNA repair. Supplementation with compounded NAD+ aims to support cellular energy, metabolism, brain health, and healthy aging.

Contraindications

Do not use NAD+ therapy if you:

  • Have a known hypersensitivity to NAD+ or any excipients in the formulation.
  • Are pregnant or breastfeeding.

Warnings and Precautions

Potential risks and side effects include:

  • Injection site reactions: Pain, redness, or swelling.
  • Digestive discomfort: Nausea, cramping, or bloating.
  • Flushing or warmth: Mild flushing may occur with NAD+ administration.
  • Allergic reactions: Rare, but possible. Seek medical help if you experience rash, difficulty breathing, or swelling.

Precautions Before Use

Inform your healthcare provider if you:

  • Have a history of cardiovascular disease, diabetes, or kidney disorders.
  • Are pregnant, planning pregnancy, or breastfeeding.
  • Are taking other medications, including prescriptions, over-the-counter drugs, vitamins, or supplements.

Administration

  • NAD+ is administered by subcutaneous injection.
  • Follow the dosing instructions provided by your healthcare provider.
  • Do not adjust or discontinue NAD+ without consulting your provider.

Common Side Effects

The most common side effects include:

  • Mild injection site irritation.
  • Nausea or stomach discomfort.
  • Headache or dizziness.

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This list does not include all possible side effects. Consult your healthcare provider regarding any adverse effects you may experience.

Important Notes

  • NAD+ therapy should only be initiated and monitored by a licensed healthcare provider.
  • If you experience a medical emergency, call 911 immediately.
  • For additional safety information, contact FDA MedWatch at 1-800-FDA-1088 or visit www.fda.gov/medwatch.

Commitment to Safety

Yucca Health is committed to providing safe, transparent, and high-quality care. We encourage patients to discuss all concerns openly with their provider to ensure the best possible treatment outcomes.